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Publications

Peer-reviewed

2024

  • Hazu, M., Guna, A., Stevens, T., Voorhees, R. M., (2024) Monitoring alpha-helical membrane protein insertion into the outer mitochondrial membrane in mammalian cells Methods in Enzymology 22 August 2024 doi: 10.1016/bs.mie.2024.07.054
  • Voorhees, R.M. , Glazier, A. Feature: Cell scientist to watch – Rebecca Voorhees J Cell Science 137(15) 01 August 2024 doi:10.1242/jcs.263415
  • Page, K., Nguyen, V., Pleiner, T., Tomaleri, G.P., Wang, M. , Guna, A., Wang, T., Chou, T., Voorhees, R. M., (2023) Role of a holo-insertase complex in the biogenesis of biophysically diverse ER membrane proteins Molecular Cell (in press) bioRxiv doi:10.1101/2023.11.28.569054v1
  • Muthukumar,, G., Stevens, T. A., Inglis, A.J., Esantsi, T.K., Saunders, R.A., Schulte, F., Voorhees, R.M., Guna, A.J., Weissman, J.S. (2023) Triaging of ⍺-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology Molecular Cell 21 March 2024 doi 10.1016/j.molcel.2024.01.028 bioRxiv doi: 10.1101/2023.08.16.553624

2023

  • Stevens, T. A., Tomaleri, G.P., Hazu, M., Wei, S., Nguyen, V. N., DeKalb, C., Voorhees, R.M., Pleiner, T. A nanobody-based strategy for rapid and scalable purification of native human protein complexes Nature Protocols 16 November 2023 doi: 10.1038/s41596-023-00904-w, bioRxiv doi:10.1101/2023.03.09.531980
  • Guna, A., Page, K., Replogle, J. R., Esantsi, T. K., Wang, M. L., Weissman, J. S., Voorhees, R. M., A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens BMC Genomics 30 October 2023 doi 10.1186/s12864-023-09754-y bioRxiv doi: 10.1101/2023.01.22.525086
  • Watson*, J.L., Seinkmane*, E., Styles*, C.T., Mihut, A., Krüger, L.K., McNally, K.E., Planelles-Herrero, V.J., Dudek, M., McCall, P.M., Barbiero, S., Vanden Oever, M., Peak-Chew, S.Y., Porebski, B.T., Zeng, A., Rzechorzek, N.M., Wong, D.C.S., Beale, A.D., Stangherlin, A., Riggi, M., Iwasa, J., Morf, M., Miliotis, C., Guna, A., Inglis, A.J., Brugués, J., Voorhees, R.M., Chambers, J.E., Meng, Q-J., O'Neill§, J.S., Edgar§, R., Derivery§, E. (2023). Macromolecular condensation buffers intracellular water potential. Nature 18 October 2023 doi: 10.1038/s41586-023-06626-z
  • Inglis, A.J., Guna, A., Merchán, A.G., Pal, A., Esantsi, T.K., Keys, H.R., Frenkel, E.M., Oania, R.S., Weissman, J.S., Voorhees, R.M. (2023) "Coupled protein quality control during nonsense mediated mRNA decay." J Cell Science 2023 doi: /10.1242/jcs.261216, bioRxiv doi: 10.1101/2021.12.22.473893
  • Pleiner, T., Hazu, M., Tomaleri, G.P., Nguyen, V. N., Januszyk K., Voorhees, R.M. (2023) "A selectivity filter in the ER membrane protein complex limits protein misinsertion at the ER" JCB 2023; 222(8) doi: 10.1083/jcb.202212007 pmid: 37199759, bioRxiv doi: 10.1101/2022.11.29.518402
    • Spotlight: Doron Rapaport, Johannes M. Herrmann; Chasing the right tail: How the ER membrane complex recognizes its substrates. J Cell Biol 7 August 2023; 222 (8): e202306035. doi: https://doi.org/10.1083/jcb.202306035

2022

  • Guna, A., Stevens T., Inglis, A., Replogle, J., Esantsi, T., Muthukumar, G., Shaffer, K., Wang, M., Pogson, A., Jones, J., Lomenick, B., Chou, T-F., Weissman, J., Voorhees, R..M. (2022) "MTCH2 is a mitochondrial outer membrane protein insertase" Science, 378(6617) doi: 10.1126/science.add1856 pmid: 36264797, bioRxiv doi: 10.1101/2022.09.15.508165
  • Guna, A., Hazu M., Tomaleri, G.P., Voorhees, R.M. (2022) "A TAle of Two Pathways: Tail-Anchored Protein Insertion at the Endoplasmic Reticulum" Cold Spring Harbor Perspectives in Biology doi: 10.1101/cshperspect.a041252 pmid: 36041783
  • McCord, R.P., Taipale, M., Teichmann, S., Voorhees, R.M., Wan, Y., Dekker, C., Sanjana, N.E. (2022) Voices on technology: The molecular biologists' ever-expanding toy box Mol Cell, 82(2): P221-226. doi: 10.1016/j.molcel.2021.12.025 pmid: 35063087

2021

  • Stangherlin, A., Wong, D.C.S., Barbiero, S., Watson, J.L., Zeng, A., Seinkmane, E., Chew, S.P., Beale, A.D., Hayter, E.A., Guna, A., Inglis, A.J., Bartolami, E.M.S., Lequeux, N., Pons, T., Day, J., van Ooijen, G., Voorhees, R.M., Bechtold, D.A., Derivery, E., Edgar, R.S., Newham, P., O'Neill, J.S. (2021) "Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology" Nature Communications. doi: 10.1101/2020.05.28.118398. pmid 34654800
  • Pleiner, T., Hazu, M., Tomaleri, G.P., Januszyk, K., Oania, R.S., Sweredoski, M.J., Moradian, A., Guna, A., Voorhees, R.M. (2021) "WNK1 is an assembly factor for the human ER membrane protein complex." Mol Cell, 81(13): 2693-2704.e12. pmid: 33964204. pmcid: PMC8254792. doi: 10.1016/j.molcel.2021.04.013 bioRxiv doi: 10.1101/2020.07.20.213066

2020

2016

  • Voorhees, R.M., Hegde, R.S. (2016) "Structure of the Sec61 channel opened by a signal sequence." Science, 351(6268): 88-91. doi: 10.1126/science.aad4992. pmid: 26721998. pmcid: PMC4700591.
  • Voorhees, R.M., Hegde, R.S. (2016) "Toward a structural understanding of co-translational protein translocation." Curr. Opin. Cell Biol., 41: 91-9. doi: 10.1016/j.ceb.2016.04.009. pmid: 27155805.

2015

  • Voorhees, R.M., Hegde, R.S. (2015) "Structures of the scanning and engaged states of the mammalian SRP-ribosome complex." eLife, 4. doi: 10.7554/eLife.07975. pmid: 26158507. pmcid: PMC4497383.

2014

  • Voorhees, R.M.†*, Fernández, I.S.*, Scheres, S.H., Hegde, R.S. (2014) "Structure of the mammalian ribosome-Sec61 complex to 3.4 Å resolution." Cell, 157(7): 1632-43. doi: 10.1016/j.cell.2014.05.024. pmid: 24930395. pmcid: PMC4081569. †: corresponding author.

2013

  • Voorhees, R.M., Mandal, D., Neubauer, C., Köhrer, C., RajBhandary, U.L., Ramakrishnan, V. (2013) "The structural basis for specific decoding of AUA by isoleucine tRNA on the ribosome." Nat. Struct. Mol. Biol., 20(5): 641-3. doi: 10.1038/nsmb.2545. pmid: 23542153. pmcid: PMC3672977.
  • Voorhees, R.M., Ramakrishnan, V. (2013) "Structural basis of the translational elongation cycle." Annu. Rev. Biochem., 82: 203-36. doi: 10.1146/annurev-biochem-113009-092313. pmid: 23746255.

2011

  • Schmeing, T.M.*, Voorhees, R.M.*, Kelley, A.C., Ramakrishnan, V. (2011) "How mutations in tRNA distant from the anticodon affect the fidelity of decoding." Nat. Struct. Mol. Biol., 18(4): 432-6. doi: 10.1038/nsmb.2003. pmid: 21378964. pmcid: PMC3072312.

2010

  • Voorhees, R.M.*, Schmeing, T.M.*, Kelley, A.C., Ramakrishnan, V. (2010) "The mechanism for activation of GTP hydrolysis on the ribosome." Science, 330(6005): 835-8. doi: 10.1126/science.1194460. pmid: 21051640. pmcid: PMC3763471.

2009

  • Voorhees, R.M., Weixlbaumer, A., Loakes, D., Kelley, A.C., Ramakrishnan, V. (2009) "Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome." Nat. Struct. Mol. Biol., 16(5): 528-33. doi: 10.1038/nsmb.1577. pmid: 19363482. pmcid: PMC2679717.
  • Schmeing, T.M.*, Voorhees, R.M.*, Kelley, A.C., Gao, Y.G., Murphy, F.V., Weir, J.R., Ramakrishnan, V. (2009) "The crystal structure of the ribosome bound to EF-Tu and aminoacyl-tRNA." Science, 326(5953): 688-94. doi: 10.1126/science.1179700. pmid: 19833920. pmcid: PMC3763470.

2008

  • Kingery, D.A.*, Pfund, E.*, Voorhees, R.M.*, Okuda, K., Wohlgemuth, I., Kitchen, D.E., Rodnina, M.V., Strobel, S.A. (2008) "An uncharged amine in the transition state of the ribosomal peptidyl transfer reaction." Chem. Biol., 15(5): 493-500. doi: 10.1016/j.chembiol.2008.04.005. pmid: 18482701. pmcid: PMC2851197.
  • Weixlbaumer, A.*, Jin, H.*, Neubauer, C., Voorhees, R.M., Petry, S., Kelley, A.C., Ramakrishnan, V. (2008) "Insights into translational termination from the structure of RF2 bound to the ribosome." Science, 322(5903): 953-6. doi: 10.1126/science.1164840. pmid: 18988853. pmcid: PMC2642913.

  • * Authors contributed equally to this work.