Preprints

  • Stangherlin, A., Wong, D.C.S., Barbiero, S., Watson, J.L., Zeng, A., Seinkmane, E., Chew, S.P., Beale, A.D., Hayter, E.A., Guna, A., Inglis, A.J., Bartolami, E.M.S., Lequeux, N., Pons, T., Day, J., van Ooijen, G., Voorhees, R.M., Bechtold, D.A., Derivery, E., Edgar, R.S., Newham, P., O’Neill, J.S. (2020) "Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology" . doi10.1101/2020.05.28.118398.

Peer-reviewed

2021

  • Pleiner, T., Hazu, M., Pinton Tomaleri, G., Januszyk, K., Oania, R.S., Sweredoski, M.J., Moradian, A., Guna, A., Voorhees, R.M. (2021) "WNK1 is an assembly factor for the human ER membrane protein complex." Mol Cell, Epub ahead of print. doi10.1016/j.molcel.2021.04.013. pmid33964204. Full text.

2020

  • Inglis, A.J., Page, K.R., Guna, A., Voorhees, R.M. (2020) "Differential Modes of Orphan Subunit Recognition for the WRB/CAML Complex." Cell Rep, 30(11): 3691-3698.e5. doi10.1016/j.celrep.2020.02.084. pmid32187542. pmcidPMC7147533.
  • Pleiner, T.*, Pinton Tomaleri, G.*, Januszyk, K.*, Inglis, A.J., Hazu, M., Voorhees, R.M. (2020) "Structural basis for membrane insertion by the human ER membrane protein complex" Science, 369(6502): 433-436. doi10.1126/science.abb5008. pmid32439656. pmcidPMC7547852. Full text.
  • Banerjee, A.K., Blanco, M.R., Bruce, E.A., Honson, D.D., Chen, L.M., Chow, A., Bhat, P., Ollikainen, N., Quinodoz, S.A., Loney, C., Thai, J., Miller, Z.D., Lin, A.E., Schmidt, M.M., Stewart, D.G., Goldfarb, D., De Lorenzo, G., Rihn, S.J., Voorhees, R.M., Botten, J.W., Majumdar, D., Guttman, M. (2020) "SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses." Cell, in press. doi10.1016/j.cell.2020.10.004. pmid33080218. pmcidPMC7543886.

2016

  • Voorhees, R.M., Hegde, R.S. (2016) "Structure of the Sec61 channel opened by a signal sequence." Science, 351(6268): 88-91. doi10.1126/science.aad4992. pmid26721998. pmcidPMC4700591.
  • Voorhees, R.M., Hegde, R.S. (2016) "Toward a structural understanding of co-translational protein translocation." Curr. Opin. Cell Biol., 41: 91-9. doi10.1016/j.ceb.2016.04.009. pmid27155805.

2015

  • Voorhees, R.M., Hegde, R.S. (2015) "Structures of the scanning and engaged states of the mammalian SRP-ribosome complex." eLife, 4. doi10.7554/eLife.07975. pmid26158507. pmcidPMC4497383.

2014

  • Voorhees, R.M.*, Fernández, I.S.*, Scheres, S.H., Hegde, R.S. (2014) "Structure of the mammalian ribosome-Sec61 complex to 3.4 Å resolution." Cell, 157(7): 1632-43. doi10.1016/j.cell.2014.05.024. pmid24930395. pmcidPMC4081569. †: corresponding author.

2013

  • Voorhees, R.M., Mandal, D., Neubauer, C., Köhrer, C., RajBhandary, U.L., Ramakrishnan, V. (2013) "The structural basis for specific decoding of AUA by isoleucine tRNA on the ribosome." Nat. Struct. Mol. Biol., 20(5): 641-3. doi10.1038/nsmb.2545. pmid23542153. pmcidPMC3672977.
  • Voorhees, R.M., Ramakrishnan, V. (2013) "Structural basis of the translational elongation cycle." Annu. Rev. Biochem., 82: 203-36. doi10.1146/annurev-biochem-113009-092313. pmid23746255.

2011

  • Schmeing, T.M.*, Voorhees, R.M.*, Kelley, A.C., Ramakrishnan, V. (2011) "How mutations in tRNA distant from the anticodon affect the fidelity of decoding." Nat. Struct. Mol. Biol., 18(4): 432-6. doi10.1038/nsmb.2003. pmid21378964. pmcidPMC3072312.

2010

  • Voorhees, R.M.*, Schmeing, T.M.*, Kelley, A.C., Ramakrishnan, V. (2010) "The mechanism for activation of GTP hydrolysis on the ribosome." Science, 330(6005): 835-8. doi10.1126/science.1194460. pmid21051640. pmcidPMC3763471.

2009

  • Voorhees, R.M., Weixlbaumer, A., Loakes, D., Kelley, A.C., Ramakrishnan, V. (2009) "Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome." Nat. Struct. Mol. Biol., 16(5): 528-33. doi10.1038/nsmb.1577. pmid19363482. pmcidPMC2679717.
  • Schmeing, T.M.*, Voorhees, R.M.*, Kelley, A.C., Gao, Y.G., Murphy, F.V., Weir, J.R., Ramakrishnan, V. (2009) "The crystal structure of the ribosome bound to EF-Tu and aminoacyl-tRNA." Science, 326(5953): 688-94. doi10.1126/science.1179700. pmid19833920. pmcidPMC3763470.

2008

  • Kingery, D.A.*, Pfund, E.*, Voorhees, R.M.*, Okuda, K., Wohlgemuth, I., Kitchen, D.E., Rodnina, M.V., Strobel, S.A. (2008) "An uncharged amine in the transition state of the ribosomal peptidyl transfer reaction." Chem. Biol., 15(5): 493-500. doi10.1016/j.chembiol.2008.04.005. pmid18482701. pmcidPMC2851197.
  • Weixlbaumer, A.*, Jin, H.*, Neubauer, C., Voorhees, R.M., Petry, S., Kelley, A.C., Ramakrishnan, V. (2008) "Insights into translational termination from the structure of RF2 bound to the ribosome." Science, 322(5903): 953-6. doi10.1126/science.1164840. pmid18988853. pmcidPMC2642913.
  • * Authors contributed equally to this work.